APTX 4869 antidote prototype

[gealatief]

Heyya there, I'm a newbie. As my introduction, I wanna share my deduction about DC's possible next files...

Maybe there'll be a time when Conan is unable to return his 17-yr-old body with the antidote prototype, because just like what Ai hv warned, his body develops a full resistance to the drug.
Since Ai have warned him[Conan] about the resistance couple times, I think it's quite possible that one day it's really going to happen.

And the antidote's effect wear off shorter than usual lately. First time Conan tries the antidote (vol. 26 Desperate Revival) it lasts for 24 hour. The second is at vol. 62-63 (The Return), the antidote still lasts for 24 hour but when Conan takes it for the second time it wears off in 4 hours.
The latest is at "The Holmes' Apprentice". When Shinichi meets Ran, it is said that it's already dinner time, but Shinichi already returns to Conan before evening in the next day. So it's not a full 24 hours, right? Anyway, normally a Tokyo-London flight's approximate time won't take longer than 17 hours.

So that means, the antidote effect wears off faster! Conan, you should be careful!^^

But I think in the end another important ingredient--the effect is as strong as paikaru--will shown and will make the antidote prototype even stronger. Good news!

Thankyou
I heart DC a lot.

[PS. So sorry for the bad grammar. Give any rave or rants anytime you like! ]

Fixed your original post with your edit, deleted your double thread - Abs.

[User 4869]

So you going to say the old Antidote will not work anymore but the new one that work will come up. How's that effect storyline and why Gosho want to add it in in the first place. Or you mean the new one is going to be better and he can be Shinichi longer. But it also possible that new antidote will have the same effect right? (24hr.)

Well, If Gosho want to make the Antidote last longer, I expect him to come up with a explanation like Conan or Haibara consume some rarely use ingredient (in some random food) by chance and know it effect their body. So she can make new antidote.

[gealatief]

So you going to say the old Antidote will not work anymore but the new one that work will come up. How's that effect storyline and why Gosho want to add it in in the first place.

of course, since the antidote is just a prototype, there must be any miscalculation or ingredient missing. Ai doesn't know about paikaru's effect until she tries it herself (vol. 24).
And yeah, if this random ingredient consumed by Conan/Ai you know how exciting the story will be^^
thanks for the response.

[sstimson]

there are two parts to the current antidote. One part is the liquor - Paikaru. The other part might be what the body is developing a resistance to - The pill or chemical that makes the body think it has a cold. Remember it takes both. Also on the question of resistance, some kinds of resistance if given enough time, do not become a problem. If the Body is constantly feed the antidote it will develop  resistance faster then say the same antidote being given over longer peroids of time between doses. The Body might forgot about the antidote and not make any antibodies againist it if the time period between doses is long enough. 

[KangarooGirl]

Actually, iirc, Conan has to have a cold in order for the antidote to work. Something about him having to be immuno-suppressed. So if Ai can figure out a way to include that into the antidote or change the molecular formula so that the body doesn't recognise it as foreign and attack it, then she may have a permanent antidote on her hands. The latter would be preferable, since having Shinichi permanently immuno-suppressed is definitely not a good thing.

[Dus]

He didn't have a cold when he wanted to go to London. So Ai is beyond that stage.

[Eve]

He didn't have a cold when he wanted to go to London. So Ai is beyond that stage.

^ this

And yes, Ai is making progress while Conan resistance is building up as a faster than expected rate

[gealatief]

Remember! Conan also didn't have cold when he first try the antidote at "Desperate Revival".
And when Conan asked for a hundred pills of antidote, Ai refused and saying the same reason--the resistance. "you'll be unable to return if you take it too much!" she said, or so.
can you imagine when Conan eats, let's say, sashimi, he returns back to Shinichi?

[User 4869]

Remember! Conan also didn't have cold when he first try the antidote at "Desperate Revival".
And when Conan asked for a hundred pills of antidote, Ai refused and saying the same reason--the resistance. "you'll be unable to return if you take it too much!" she said, or so.
can you imagine when Conan eats, let's say, sashimi, he returns back to Shinichi?

Actually he has a cold in Desperate Revival. It's side effect after the operation. That's why no one take notice when Ai wear face-mask. Because Conan should wear it anyway.

But I agree that she already past the "cold" state. as show in the London arc.

[gealatief]

Also when Ai drinks paikaru, her condition is totally okay

[User 4869]

Also when Ai drinks paikaru, her condition is totally okay

Oh, she has a little cold that morning and say the cold greater since Pisco leave her lie on a cold floor.


I actually can't sit properly on my chair whenever the two has cold. Once Conan get a cold and what happen next is

Spoiler:

He has to solve case without his voice

[sstimson]

You missed my point. I disagree that the cold part is over

I was trying ( and failing ) to say that Hairaba has included
the cold part in the pill. If you remember, she once created
a pill to cause symptoms of a cold. What I am trying to say
is now she has both the liquor and cold causing in one pill

[User 4869]

You missed my point. I disagree that the cold part is over

I was trying ( and failing ) to say that Hairaba has included
the cold part in the pill. If you remember, she once created
a pill to cause symptoms of a cold. What I am trying to say
is now she has both the liquor and cold causing in one pill

Isn't Dus who say cold part is over. I agree with him. And "cold part is over" mean Conan don't need to get cold in order for antidote to work. If somehow Haibara can create artificial cold. Isn't that the same thing?


she once created a pill to cause symptoms of a cold<<<
Isn't that movie 7

[kyuuketsuki]

You missed my point. I disagree that the cold part is over

I was trying ( and failing ) to say that Hairaba has included
the cold part in the pill. If you remember, she once created
a pill to cause symptoms of a cold. What I am trying to say
is now she has both the liquor and cold causing in one pill

Isn't Dus who say cold part is over. I agree with him. And "cold part is over" mean Conan don't need to get cold in order for antidote to work. If somehow Haibara can create artificial cold. Isn't that the same thing?


she once created a pill to cause symptoms of a cold<<<
Isn't that movie 7

Yes it is, and therefore it is non-canon. Ergo, it is more likely that Haibara has figured out how to get the antidote to work without a compromised immune system. Besides... If that WERE the case, he would still have a cold as Shinichi, and that is clearly not on the case on the plane nor in London. He seems to be in perfect health in both instances.

However, it is still likely she is still refining the elements of Paikal to get the antidote... So if that is the case this is not the true antidote... It is more like a temporary treatment. When haibara gets the structure and chemical composition, she should be able to reverse the effects completely, regardless of whether Shinichi has developed a resistance to the current treatment. This is assuming that Paikal is just treating the symptoms if you will rather than actually affecting his condition. Neither of which can be confirmed until gosho releases some info on the current prototype antidote.

[Puto]

Furthermore, it seems the resistance to the prototype-antidote "wears off", so to speak. It worked for 24 hours during the Desperate Revival arc, and it worked for 24 hours again the first time he took it during that "Murderer: Shin'ichi Kudô" arc. It was only the second one he took that didn't last long. Furthermore, when he was going to London, Haibara said "Remember that if you take the second pill too soon, it won't last as long," and he did just that. That's why the second pill didn't last 24 hours, because he had recently taken one when getting on the plane and so still had some resistance.

Oh, by the way, guys. It's "baigar." Paikaru is just the direct romanisation of the Japanese word used to refer to that alcohol. It's just as awkward as referring to Vermouth as "Berumotto."